I frequently experience withdrawals (after highs) from cannabis coming into my apartment second hand. People who have never experienced THC withdrawals tend not believe it but it is true. There’s not been just one withdrawal in my life. As a separate event I had a seizure, and after researching found others online who had the same after a marijuana relapse. It was not laced... others who smoked with me were completely fine, and I knew the guy who grew it. Why would I make this up. You can look up the symptoms of marijuana/THC withdrawal. They are well known, as is serotonin syndrome which I believe is what caused the seizure. I am not stupid though it seems you would like me to be so you can more easily write off what I am saying. I’m glad those people you mentioned feel better with weed. Maybe they do not have addictive personalities. That being said, if they use it (with THC) frequently it is unlikely they would not experience a strong withdrawal effect if they were to stop suddenly. Almost all would.
What woke me up, as you say, was maybe the wealthiest guy I know saying, in response to me saying I don’t smoke, “but if somebody passed you some you wouldn’t turn it down because that’s the kind of life you live” (I’m paraphrasing). I realized that my lack of self discipline and over-agreeableness was obvious to those who know how to spot it.
I don’t blame marijuana for anything. I am aware of what it is, and that probably my use pattern was somewhat unusual (in volume & frequency). I made those errors in judgement after hearing so many lies about medicinal qualities. I remember telling myself and others how good it was for people, that it prevented cancer and treated pain. I now know I was simply living in a cloud.
Merry Christmas and if I don’t see you, happy new year!
My research and experience has shown that cannabis sensitivity is significantly affected by usage. Apparently it has to do with the way cannabinoids will reduce the thickness of the myelin sheath around neurons. Over time, the sheath rebuilds, but it may never rebuild fully in certain cases. During heavy use, the cannabinoids fill the space the thicker sheath area used to occupy, reducing sensitivity. After quitting, the myelin is left more exposed while the sheath takes time to rebuild.
Many people do not get very high their first time, and only feel the strong effects after the second or third time. This is one example of how cannabinoid receptors in the brain will develop in response to usage.
During periods of heavy use, the receptors are overwhelmed, and the psychological effects are also being counterbalanced by the adaptive chemistry of the brain. So while heavy usage builds tolerance, it also develops more receptors/sensitivity, which are effectively latent during heavy use.
It’s similar to working out a lot so you are tired all the time, but then you take a break from your workout routine and you are really full of energy for a while.
In my case I relapsed a short time after going through a full withdrawal (about one month). Due to this I was at maximum sensitivity (lots of receptors) and low tolerance, a combination which produced the serotonin imbalance (serotonin syndrome) which is likely what resulted in the seizure effect.
The development of cannabinoid receptors permanently alters the brain. Due to my frequent use I will likely always have an enhanced sensitivity to the substance. Which is why I am not hesitant to point out the negatives to others!
Courts and legislators rarely understand science to the level I have described, which I why I always support limited government and maximum individual liberties. And I do extend this to being able to choose ones own “medicine”. I will also always advocate a scientific approach in doing so. I also happen to know far more about cannabis-related neurochemistry than I usually care to admit!
Important to note that CBD & THC may have different effects! The 2nd study you linked involves an extract created from CBD!
Both studies suggest potential for therapeutic applications, while offering no conclusive proof that it works or is safe! EHP-101 is still in clinical trials! (albeit 2nd phase)
The mechanism from the 1st study involves attenuating inflammation (inflammation which causes myelin destruction), and thereby reducing the destruction... It seems that the effect in a healthy brain, which doesn’t experience inflammation that would need attenuating, may be the opposite!
Serotonin syndrome, or a related but unnamed syndrome, resulting from cannabis appears to be somewhat rare, as surely was my usage pattern at that time!
To have confirmation bias, I would have to have interest in maintaining my beliefs vs interest in maintaining accuracy. Would cause me far less friction to go along with the zeitgeist of the times that cannabis is a wonder drug! Far more likely that those promoting its benefits and widespread use/acceptance are guilty of such bias!
I frequently experience withdrawals (after highs) from cannabis coming into my apartment second hand. People who have never experienced THC withdrawals tend not believe it but it is true. There’s not been just one withdrawal in my life. As a separate event I had a seizure, and after researching found others online who had the same after a marijuana relapse. It was not laced... others who smoked with me were completely fine, and I knew the guy who grew it. Why would I make this up. You can look up the symptoms of marijuana/THC withdrawal. They are well known, as is serotonin syndrome which I believe is what caused the seizure. I am not stupid though it seems you would like me to be so you can more easily write off what I am saying. I’m glad those people you mentioned feel better with weed. Maybe they do not have addictive personalities. That being said, if they use it (with THC) frequently it is unlikely they would not experience a strong withdrawal effect if they were to stop suddenly. Almost all would.
What woke me up, as you say, was maybe the wealthiest guy I know saying, in response to me saying I don’t smoke, “but if somebody passed you some you wouldn’t turn it down because that’s the kind of life you live” (I’m paraphrasing). I realized that my lack of self discipline and over-agreeableness was obvious to those who know how to spot it.
I don’t blame marijuana for anything. I am aware of what it is, and that probably my use pattern was somewhat unusual (in volume & frequency). I made those errors in judgement after hearing so many lies about medicinal qualities. I remember telling myself and others how good it was for people, that it prevented cancer and treated pain. I now know I was simply living in a cloud.
Merry Christmas and if I don’t see you, happy new year!
My research and experience has shown that cannabis sensitivity is significantly affected by usage. Apparently it has to do with the way cannabinoids will reduce the thickness of the myelin sheath around neurons. Over time, the sheath rebuilds, but it may never rebuild fully in certain cases. During heavy use, the cannabinoids fill the space the thicker sheath area used to occupy, reducing sensitivity. After quitting, the myelin is left more exposed while the sheath takes time to rebuild.
Many people do not get very high their first time, and only feel the strong effects after the second or third time. This is one example of how cannabinoid receptors in the brain will develop in response to usage.
During periods of heavy use, the receptors are overwhelmed, and the psychological effects are also being counterbalanced by the adaptive chemistry of the brain. So while heavy usage builds tolerance, it also develops more receptors/sensitivity, which are effectively latent during heavy use.
It’s similar to working out a lot so you are tired all the time, but then you take a break from your workout routine and you are really full of energy for a while.
In my case I relapsed a short time after going through a full withdrawal (about one month). Due to this I was at maximum sensitivity (lots of receptors) and low tolerance, a combination which produced the serotonin imbalance (serotonin syndrome) which is likely what resulted in the seizure effect.
The development of cannabinoid receptors permanently alters the brain. Due to my frequent use I will likely always have an enhanced sensitivity to the substance. Which is why I am not hesitant to point out the negatives to others!
Courts and legislators rarely understand science to the level I have described, which I why I always support limited government and maximum individual liberties. And I do extend this to being able to choose ones own “medicine”. I will also always advocate a scientific approach in doing so. I also happen to know far more about cannabis-related neurochemistry than I usually care to admit!
Cheers!
Important to note that CBD & THC may have different effects! The 2nd study you linked involves an extract created from CBD!
Both studies suggest potential for therapeutic applications, while offering no conclusive proof that it works or is safe! EHP-101 is still in clinical trials! (albeit 2nd phase)
The mechanism from the 1st study involves attenuating inflammation (inflammation which causes myelin destruction), and thereby reducing the destruction... It seems that the effect in a healthy brain, which doesn’t experience inflammation that would need attenuating, may be the opposite!
Here is a study which reviews some dangers & shows images of demyelination resulting from cannabis use: https://www.dalgarnoinstitute.org.au/images/resources/pdf/cannabis-conundrum/AdverseStructuralFunctionalEffectsofMarijuanaOnBrain2016.pdf
Serotonin syndrome, or a related but unnamed syndrome, resulting from cannabis appears to be somewhat rare, as surely was my usage pattern at that time!
To have confirmation bias, I would have to have interest in maintaining my beliefs vs interest in maintaining accuracy. Would cause me far less friction to go along with the zeitgeist of the times that cannabis is a wonder drug! Far more likely that those promoting its benefits and widespread use/acceptance are guilty of such bias!