u/NuclearOption isn't wrong though. See my sibling post for citations.
mRNA vaccines cannot modify DNA. mRNA can only be used to transcribe proteins by the ribosomes in the cellular cytoplasm. It cannot enter the nucleus.
The dangers with the Pfizer and Moderna vaccines lie in their use of polyethylene glycols to stabilize the lipid nanoparticles for transport into the cell. People are reacting to these, and if the anaphylaxis isn't treated rapidly, they can die.
Not everyone reacts to PEG, however, but I'd suggest reading my sibling post if you want a) citations and b) commentary on a COVID vaccine that absolutely is concerning.
Did they get round the Antibody Dependant Enhancement (ADE) ?
Last I checked, the Pfizer application to the FDA admitted they had no information on such a possibility. And given that ADE has been the cause of all previous Corona vaccine trials failing, I'd have to think the current rollout is a huge trial in itself :)
u/NuclearOption isn't wrong though. See my sibling post for citations.
mRNA vaccines cannot modify DNA. mRNA can only be used to transcribe proteins by the ribosomes in the cellular cytoplasm. It cannot enter the nucleus.
The dangers with the Pfizer and Moderna vaccines lie in their use of polyethylene glycols to stabilize the lipid nanoparticles for transport into the cell. People are reacting to these, and if the anaphylaxis isn't treated rapidly, they can die.
Not everyone reacts to PEG, however, but I'd suggest reading my sibling post if you want a) citations and b) commentary on a COVID vaccine that absolutely is concerning.
Did they get round the Antibody Dependant Enhancement (ADE) ?
Last I checked, the Pfizer application to the FDA admitted they had no information on such a possibility. And given that ADE has been the cause of all previous Corona vaccine trials failing, I'd have to think the current rollout is a huge trial in itself :)
I can't answer that. My depth of knowledge on this subject is limited strictly to those things that I've researched.
I'd suggest pinging u/HuntersDealer who actually DOES work in the industry, in research, and whose expertise this tickles in all the right places.