My fixation on PEG is mostly with regards to the reality that the side effects people are witnessing are exclusively from its use, as you noted. Of course, I may be grossly exaggerating it in effort to direct people's attention away from their absurd obsession with mRNA (somehow being stupid enough to think that it will modify their genome).
You're right, of course. My opinion is that the risk of adverse reactions from PEGylated nanoparticles is so comparatively minor that if you do the math, you're probably something like 50 times more likely to die from COVID-19 even with the exaggerated figures than you are to have an adverse reaction.
But, I think part of my whinging is due in part to frustration. I do greatly appreciate your clarifications and defense of this strategy. Thank you so much.
My opinion is also that I sincerely hope the Pfizer and Moderna vaccines demonstrate a safe delivery of mRNA for the reasons that I understand these were originally thought up in the late 1980s as a treatment for cancer (e.g. cancer vaccinations). If this is successful, then it means that the delivery mechanism works, and we might see the COVID-19 fallout lead toward workable vaccinations for common cancers.
FWIW, I don't have any idea what I'm talking about, because I'm a programmer. I have nothing to do with the medical industry. I do, however, happily read whatever research is available at any given time because I'm a bit touched in the head and maybe borderline crazy. But what frustrates me is that this information is freely available, the research is quite sound, and there's no reason for idiots to start spreading completely false information that isn't supported by biochemistry.
I really hate conspiracies. Doubly so when it's completely fallacious, such as the absolutely asinine claims that mRNA is going to modify our DNA and make us slaves to the Bill Gates mastermind or some such nonsense. If some dumbass programmer like myself can figure out what mRNA does, I don't understand why so many people eat up the conspiracy that it does something impossible.
Thank you again for stepping in and bringing real experience to this conversation. It's sorely needed. There's only so much an amateur such as myself can argue without requiring authoritative assistance.
The thing is that 99.9% of the population is what I would posit are "headline-educated." They're unwilling to read beyond headlines, and in most cases are consumed by a fascination with conspiracy that has no basis on reality. It's unfortunate, but it's the reality that we have to face. Those of us who do try to educate ourselves--even if we often fail--do so for a variety of reasons. I can't speak to the others here who follow suit, but my line of work requires a degree of analytical thinking (systems design, development, debugging, etc); consequently, I'm not entirely fond of taking rumors at face value. It does a disservice to humanity to ignore the plethora of information available on the Internet at our fingertips. Yet here we are.
I'm grateful there are people like you posting on TDW to help keep those few of us who actually do read honest. My understanding on this matter is exceedingly limited, but I know enough to debate the conspiracists on the grounds that I have at least some idea how this technology functions (even at my most basic level of understanding, it's not hard to see how even if there's a TON of research and effort that goes into the what and the why).
I am a bit disappointed that someone downvoted you, but it doesn't really surprise me: No one likes to be told their conspiratorial line of thinking is wrong. Not when it's a strongly held conviction.
Once again, I find myself thanking you for sharing your knowledge. I've never been hugely interested in biology, but your "niche" industry is awfully fascinating, even to laypersons such as myself. Know that there are at least some of us who are cheering you on from the sidelines, because your efforts aren't in vain. We know that one day, you'll develop therapeutics for all manner of diseases. This is really just the beginning of a long and fruitful journey.
My fixation on PEG is mostly with regards to the reality that the side effects people are witnessing are exclusively from its use, as you noted. Of course, I may be grossly exaggerating it in effort to direct people's attention away from their absurd obsession with mRNA (somehow being stupid enough to think that it will modify their genome).
You're right, of course. My opinion is that the risk of adverse reactions from PEGylated nanoparticles is so comparatively minor that if you do the math, you're probably something like 50 times more likely to die from COVID-19 even with the exaggerated figures than you are to have an adverse reaction.
But, I think part of my whinging is due in part to frustration. I do greatly appreciate your clarifications and defense of this strategy. Thank you so much.
My opinion is also that I sincerely hope the Pfizer and Moderna vaccines demonstrate a safe delivery of mRNA for the reasons that I understand these were originally thought up in the late 1980s as a treatment for cancer (e.g. cancer vaccinations). If this is successful, then it means that the delivery mechanism works, and we might see the COVID-19 fallout lead toward workable vaccinations for common cancers.
FWIW, I don't have any idea what I'm talking about, because I'm a programmer. I have nothing to do with the medical industry. I do, however, happily read whatever research is available at any given time because I'm a bit touched in the head and maybe borderline crazy. But what frustrates me is that this information is freely available, the research is quite sound, and there's no reason for idiots to start spreading completely false information that isn't supported by biochemistry.
I really hate conspiracies. Doubly so when it's completely fallacious, such as the absolutely asinine claims that mRNA is going to modify our DNA and make us slaves to the Bill Gates mastermind or some such nonsense. If some dumbass programmer like myself can figure out what mRNA does, I don't understand why so many people eat up the conspiracy that it does something impossible.
Thank you again for stepping in and bringing real experience to this conversation. It's sorely needed. There's only so much an amateur such as myself can argue without requiring authoritative assistance.
The thing is that 99.9% of the population is what I would posit are "headline-educated." They're unwilling to read beyond headlines, and in most cases are consumed by a fascination with conspiracy that has no basis on reality. It's unfortunate, but it's the reality that we have to face. Those of us who do try to educate ourselves--even if we often fail--do so for a variety of reasons. I can't speak to the others here who follow suit, but my line of work requires a degree of analytical thinking (systems design, development, debugging, etc); consequently, I'm not entirely fond of taking rumors at face value. It does a disservice to humanity to ignore the plethora of information available on the Internet at our fingertips. Yet here we are.
I'm grateful there are people like you posting on TDW to help keep those few of us who actually do read honest. My understanding on this matter is exceedingly limited, but I know enough to debate the conspiracists on the grounds that I have at least some idea how this technology functions (even at my most basic level of understanding, it's not hard to see how even if there's a TON of research and effort that goes into the what and the why).
I am a bit disappointed that someone downvoted you, but it doesn't really surprise me: No one likes to be told their conspiratorial line of thinking is wrong. Not when it's a strongly held conviction.
Once again, I find myself thanking you for sharing your knowledge. I've never been hugely interested in biology, but your "niche" industry is awfully fascinating, even to laypersons such as myself. Know that there are at least some of us who are cheering you on from the sidelines, because your efforts aren't in vain. We know that one day, you'll develop therapeutics for all manner of diseases. This is really just the beginning of a long and fruitful journey.