Philosophically, they cannot adapt. They are always in the pursuit of perfection, and anything less is unacceptable. They allow perfect to be the enemy of good.
They are obsessed with identity politics to the point where it is a religion, which keeps them blind to any new ideas.
Being so propagandized by the media, they severely underestimate their opposition (us). They genuinely seem to believe we're all a bunch of wannabe slave owning Confederates, and therefore they have no genuine understanding of us or what we believe in.
When they are outmatched in debates, their standard response is to stop the discussion, and I think this is because they're afraid to go further, because 1) they realize they have nothing to say on important topics, and 2) that might shake the foundation of what they believe (better to live in a comfortable bubble than in a dangerous real world).
The idea of diversity hires, political correctness, etc. tends to lead to incompetence in whatever organization they're involved in, and results suffer because of it.
On the whole, they're very weak at controlling their emotions, especially anger, and when you get very emotional, you're not thinking clearly, and when you're not thinking clearly you start making mistakes.
I think one of the reasons they're so militant in their beliefs is not just because of propaganda, but because the worldview they've built is so fragile that they must protect it at all costs, or else, as Jordan Peterson would say, they'll be thrust into chaos.
From my experience, they genuinely believe that by obeying whatever the government says and even swelling the size of government, they are being patriotic, and they're very proud of it, not understanding the long term danger of that.
Now, I know a lot of this is common knowledge and self apparent, but I think it's a good idea to create a catalogue of potential weaknesses (especially psychological). The left has immense power right now with their trifecta of government, media, and big tech. I feel one of the best ways to take them down is to have them rot from within, and these are immense blind spots just begging to be exploited, and by seeking out as many potential soft points as possible, we could brainstorm on how to do just that.
They don't want kids. Focus your life in a way that helps you get the most resources in the shortest time, then have as many kids as you can handle and home school them.
They don't care for greatness. If pedes got into science, tech, media and so on they would dominate.
With 80 million you can create your own isolated economy and infiltrate them at the same time.
This will take a bit, but if people get serious they have no chance.