Scottish independence polled at something like 20% , after one year of serious campaigning it got about 45%, and they will certainly vote for independence if they have another referendum
UKIP were seen as fringe nuts, but they eventually gained enough momentum to force a vote. It took about 15 years but it happened
When the government fails the people, they have the right to form a new government. Texas secession qualifies.
The US has long been on a path to Balkanization.