Not exactly. mRNA determines the order of amino acids to be used in the formation of a protein. Protein folding is mostly controlled by how those amino acids interact with each other.
mRNA make proteins through a series of processes. In short, once it enters the cell, the ribosomes inside the cell translate the mRNA from forward to reverse and generates amino acid sequences. Together, the amino acids form a protein. The actual folding occurs when the amino acid sequences are sent to the ER of the cell, where the protein is glycosylated. Then it becomes a soluble, folded protein.
Proteins are just chains of amino acids that fold and bend based on how the AAs interact with one another. The nMRNA just directs the order of the amino acid chain then, for the most part, chemistry and physics take over for the folding.
Basically mRNA determined the order of the AAs in a chain
Then the AAs play off one another to create secondary structures (typically a spiral or a sheet) along the chain
Those secondary structures fold into each other to create the tertiary structure.
Sometimes, those tertiary structures will combine with others to produce a quaternary structure.
All the mRNA directly influences is the primary structure, ie the order of amino acids in the chain.
Not exactly. mRNA determines the order of amino acids to be used in the formation of a protein. Protein folding is mostly controlled by how those amino acids interact with each other.
Thanks for the clarification. So it's how the proteins are made, not folded?
mRNA make proteins through a series of processes. In short, once it enters the cell, the ribosomes inside the cell translate the mRNA from forward to reverse and generates amino acid sequences. Together, the amino acids form a protein. The actual folding occurs when the amino acid sequences are sent to the ER of the cell, where the protein is glycosylated. Then it becomes a soluble, folded protein.
Well a protein being “made” does include folding.
Proteins are just chains of amino acids that fold and bend based on how the AAs interact with one another. The nMRNA just directs the order of the amino acid chain then, for the most part, chemistry and physics take over for the folding.
Basically mRNA determined the order of the AAs in a chain
Then the AAs play off one another to create secondary structures (typically a spiral or a sheet) along the chain
Those secondary structures fold into each other to create the tertiary structure.
Sometimes, those tertiary structures will combine with others to produce a quaternary structure.
All the mRNA directly influences is the primary structure, ie the order of amino acids in the chain.