RNA is toxic and causes liver damage/inflammation amoungst many other things, probably the reason for bells palsy
The vaccine is mRNA-based not RNA. mRNA is extremely unstable outside the cellular cytoplasm. That's part of the reason why the vaccines have to be stored at such a low temperature.
The other problem, and the reason why the Pfizer vaccine has to be colder, is because of the genetic optimizations that were done to increase the transcription rate of proteins from the mRNA. The Moderna vaccine doesn't appear to do this, thus it's more stable at higher temperatures than the Pfizer vaccine.
As I posted in another comment, the reactions causing various things ranging from anaphylaxis to alleged Bell's Palsy cases are probably from the polyethylene glycol-stabilized lipid nanoparticles. PEG is generally considered safe, biologically inert, and non-toxic, but we know it can provoke an immune response.
I highly suspect that if there's a problem with this vaccine, it's from the PEG used to stabilize the lipid capsoids, which are used as the delivery mechanism.
Why the fuck did they not ship the doses on dry ice? I was told several months ago that there'd be a huge dry ice shortage, but that never happened. This should be common sense for any pharma company.
The vaccine is mRNA-based not RNA. mRNA is extremely unstable outside the cellular cytoplasm. That's part of the reason why the vaccines have to be stored at such a low temperature.
The other problem, and the reason why the Pfizer vaccine has to be colder, is because of the genetic optimizations that were done to increase the transcription rate of proteins from the mRNA. The Moderna vaccine doesn't appear to do this, thus it's more stable at higher temperatures than the Pfizer vaccine.
As I posted in another comment, the reactions causing various things ranging from anaphylaxis to alleged Bell's Palsy cases are probably from the polyethylene glycol-stabilized lipid nanoparticles. PEG is generally considered safe, biologically inert, and non-toxic, but we know it can provoke an immune response.
I highly suspect that if there's a problem with this vaccine, it's from the PEG used to stabilize the lipid capsoids, which are used as the delivery mechanism.
Why the fuck did they not ship the doses on dry ice? I was told several months ago that there'd be a huge dry ice shortage, but that never happened. This should be common sense for any pharma company.
They are, apparently, but the question is how long you can warm it up to room temp while still remaining viable.