Serious question from a molecular biologist and armchair immunologist (at best):
I can link the white paper if you’d like, but there were animal studies done in ferrets where they were vaccinated and then later given covid and died. The hypothesis I suppose (maybe not of the paper, but of many who reference it) is that the vaccine creates “non-neutralizing” antibodies that do not prevent infection and seem to enhance the adverse immune response to the wild virus. Without further studies we can’t really say anything for sure, so I guess I’m asking for an opinion.
Do the mRNA vaccines produce these useless antibodies that worsen symptoms from the actual virus because of the specific type of virus, and the fact that they’re trying to immunize people from getting a coronavirus no worse than the flu?
I was thinking about this earlier, and my uneducated opinion is that the spike protein that the vaccines cause cells to produce is not being produced in the “correct” conformation. And by correct, I mean the conformation of the spike protein when the virus is actively infecting someone and entering a cell. The spike protein on the virus itself is surrounded by other coat proteins, which probably affects the spike protein’s secondary/tertiary structures.. and companies like Pfizer just took the COVID-19 genome and mass produced mRNA corresponding to the spike protein, but this differs from its native conformation when displayed on the viral coat?
For non biologists: compare protein on the virus as a key that fits a lock. My uneducated guess is that the vaccine produces the correct protein by definition, but it doesn’t fit into the same lock because they didn’t produce the key in the right shape
The thought is that you get autoimmune effects and potentially cytokine storm because there must be some kind of homology between the spike protein and other proteins that the body naturally produces. More cycles of antigen means more antibodies each time which means a bigger autoimmune response.
I don't know why there hasn't been more done to figure this out, I assume it's because the common cold was never thought to be a big enough deal.
Friendly reminder: there is NO such thing as a "vaccine" for the coronavirus family of viruses aka "the common cold"
Serious question from a molecular biologist and armchair immunologist (at best):
I can link the white paper if you’d like, but there were animal studies done in ferrets where they were vaccinated and then later given covid and died. The hypothesis I suppose (maybe not of the paper, but of many who reference it) is that the vaccine creates “non-neutralizing” antibodies that do not prevent infection and seem to enhance the adverse immune response to the wild virus. Without further studies we can’t really say anything for sure, so I guess I’m asking for an opinion.
Do the mRNA vaccines produce these useless antibodies that worsen symptoms from the actual virus because of the specific type of virus, and the fact that they’re trying to immunize people from getting a coronavirus no worse than the flu?
I was thinking about this earlier, and my uneducated opinion is that the spike protein that the vaccines cause cells to produce is not being produced in the “correct” conformation. And by correct, I mean the conformation of the spike protein when the virus is actively infecting someone and entering a cell. The spike protein on the virus itself is surrounded by other coat proteins, which probably affects the spike protein’s secondary/tertiary structures.. and companies like Pfizer just took the COVID-19 genome and mass produced mRNA corresponding to the spike protein, but this differs from its native conformation when displayed on the viral coat?
For non biologists: compare protein on the virus as a key that fits a lock. My uneducated guess is that the vaccine produces the correct protein by definition, but it doesn’t fit into the same lock because they didn’t produce the key in the right shape
The thought is that you get autoimmune effects and potentially cytokine storm because there must be some kind of homology between the spike protein and other proteins that the body naturally produces. More cycles of antigen means more antibodies each time which means a bigger autoimmune response.
I don't know why there hasn't been more done to figure this out, I assume it's because the common cold was never thought to be a big enough deal.