Its not 11ng of fentanyl he took, he took enough to have 11ng per milliliter in his blood. The dose he took may have been over 1000 ng or 1 mg which is fatal.
Probably at least 5.7 liters of blood in a 6+ foot 230 pound male. That works out to about 62 micrograms in his blood. (Plus an unknown amount in his other tissues, plug an unknown amount in his digestive system that had not yet permeated into his tissues.)
5.7 l -> 5700 ml * 11ng/ml = 62700 ng = 62.7 mcg
negative powers of 1000 by mass are grams (g), milligrams (mg), micrograms (mcg or ug or μg) , nanograms (ng). There is a grid format for keeping units straight while doing dimensional analysis with pen and paper. It is very handy.
If I'm remembering today's testimony correctly, the pills the lab tested weighed about 300 milligrams. The fentanyl concentration was "less than 1%", but apparently not much less. Figure about 2 milligrams per pill - potentially fatal by itself.
See my other comment in this thread. You are UNDERcalculating how much fent he had to take to get those blood levels in his body. Fent volume of distribution is about 4L/kg, not just total L of blood.
Also, oral fent bioavailability is only 33%, so what was in his body was only 1/3 of what he took.
Moreover, if those blood levels were free fent (ie not protein bound) then it would be even more, since fent is 80-85% protein bound.
Its not 11ng of fentanyl he took, he took enough to have 11ng per milliliter in his blood. The dose he took may have been over 1000 ng or 1 mg which is fatal.
Probably at least 5.7 liters of blood in a 6+ foot 230 pound male. That works out to about 62 micrograms in his blood. (Plus an unknown amount in his other tissues, plug an unknown amount in his digestive system that had not yet permeated into his tissues.)
5.7 l -> 5700 ml * 11ng/ml = 62700 ng = 62.7 mcg
negative powers of 1000 by mass are grams (g), milligrams (mg), micrograms (mcg or ug or μg) , nanograms (ng). There is a grid format for keeping units straight while doing dimensional analysis with pen and paper. It is very handy.
If I'm remembering today's testimony correctly, the pills the lab tested weighed about 300 milligrams. The fentanyl concentration was "less than 1%", but apparently not much less. Figure about 2 milligrams per pill - potentially fatal by itself.
See my other comment in this thread. You are UNDERcalculating how much fent he had to take to get those blood levels in his body. Fent volume of distribution is about 4L/kg, not just total L of blood.
Also, oral fent bioavailability is only 33%, so what was in his body was only 1/3 of what he took.
Moreover, if those blood levels were free fent (ie not protein bound) then it would be even more, since fent is 80-85% protein bound.