Our hypothesis that chloroquine might inhibit replication of the SARS coronavirus1
has been confirmed in two independent in-vitro studies.Researchers at the Belgian Catholic University of Leuven found that chloroquine inhibited SARS coronavirus replication with a 50% effective concentration of 8·8 (SE 1·2) μmol/L, within the range of blood concentrations achievable during antimalarial treatment.The dose inducing 50% cytostatic activity was much higher (261·3 [14·5] μmol/L). Time-of-addition experiments indicated that chloroquine affected an early stage of SARS coronavirus replication.7
Researchers at the Centers for Disease Control and Prevention (Atlanta, GA, USA) reported potent anti-SARS coronavirus effects of chloroquine in vitro, attributable to a deficit in the glycosylation of the SARS coronavirus receptor ACE2.8
Again, the antiviral drug concentrations were not cytotoxic. If animal models confirm these results, chloroquine might represent a valuable therapeutic option if SARS re-emerges.
Look up the definition of in-vitro studies. This establishes a logical possibility. There are now several trials undergoing worldwide testing the in-vivo effects in a rigorous manner. It could work. I sincerely hope it does. But this is not settled science.
HIV =/= SARS COVID. Like I said, it's totally plausible, and I am hopeful, but we don't have the evidence that it works for this virus yet. This shit is complicated. Promising results from a tiny non-randomized trial in France + a letter from a Hassidic Jewish doctor are awesome, and I'm not that concerned of the one RCT showing ineffectiveness in China, but the jury is still very much out IMO.
Yup- https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(06)70361-9/fulltext
Look up the definition of in-vitro studies. This establishes a logical possibility. There are now several trials undergoing worldwide testing the in-vivo effects in a rigorous manner. It could work. I sincerely hope it does. But this is not settled science.
Yes, but they have also done studies where viral load in HIV patients were reduced. Its in the same linked report. So it is more than promising.
HIV =/= SARS COVID. Like I said, it's totally plausible, and I am hopeful, but we don't have the evidence that it works for this virus yet. This shit is complicated. Promising results from a tiny non-randomized trial in France + a letter from a Hassidic Jewish doctor are awesome, and I'm not that concerned of the one RCT showing ineffectiveness in China, but the jury is still very much out IMO.