Probably going to get downvoted for this. I'm HOPING AND PRAYING that Hydrochlorine is going to be the silver bullet. I STRONGLY believe that patients should have the right to take it if they desire.
All that to say, the evidence base is weak. We have a small non-randomized trial in France (very promising) and a letter from a Hassidic doctor in NYC. The invitro study basically said that injecting this drug directly into cells slowed the replication of the virus. In-vitro studies establish logical pluasible causal mechanisms. In vivo studies establish human subject trials that establish whether or not it works in the real world.
Like I said, I am HOPEFUL about this drug combo. But I don't get why we are all putting all of our eggs in one basket. We have several ongoing trials that will better inform whether or not it works. Like GEOTUS said maybe it works, maybe it doesn't. For some patients, they have nothing to lose. But before we start panic buying this medicine, we should know whether it actually works. It is not settled.
Read the study carefully (use translate). The patients that did not get chloroquine got antivirals for which there is also not a blind study. The Chinese protocol includes some medication always.
Everyone got the anti-virals, both treatment and control conditions. The point being that while chloroquine may be effective in some cases, it may not be better than our best "business-as-usual" treatment, which is still allowing thousands of people worldwide to die. This was a small sample, and I hope the results of larger trials will be encouraging, but my point is that everyone on this site is acting like hydrohlorine is going to be a miracle cure for COVID that completely fixes everything.
Yeah, that shit is moronic. Patients should be able to take it. Doctors should be able to prescribe it off-label. It's approved for that at the national level... Not saying this shouldn't be used, just saying this site is off its ass about chloroquine on emotion rather than fact.
Probably going to get downvoted for this. I'm HOPING AND PRAYING that Hydrochlorine is going to be the silver bullet. I STRONGLY believe that patients should have the right to take it if they desire.
That said, there was some disappointing evidence (albeit from a Chinese university) today: http://subject.med.wanfangdata.com.cn/UpLoad/Files/202003/43f8625d4dc74e42bbcf24795de1c77c.pdf
All that to say, the evidence base is weak. We have a small non-randomized trial in France (very promising) and a letter from a Hassidic doctor in NYC. The invitro study basically said that injecting this drug directly into cells slowed the replication of the virus. In-vitro studies establish logical pluasible causal mechanisms. In vivo studies establish human subject trials that establish whether or not it works in the real world.
Like I said, I am HOPEFUL about this drug combo. But I don't get why we are all putting all of our eggs in one basket. We have several ongoing trials that will better inform whether or not it works. Like GEOTUS said maybe it works, maybe it doesn't. For some patients, they have nothing to lose. But before we start panic buying this medicine, we should know whether it actually works. It is not settled.
Read the study carefully (use translate). The patients that did not get chloroquine got antivirals for which there is also not a blind study. The Chinese protocol includes some medication always.
Everyone got the anti-virals, both treatment and control conditions. The point being that while chloroquine may be effective in some cases, it may not be better than our best "business-as-usual" treatment, which is still allowing thousands of people worldwide to die. This was a small sample, and I hope the results of larger trials will be encouraging, but my point is that everyone on this site is acting like hydrohlorine is going to be a miracle cure for COVID that completely fixes everything.
Even if you disagree with patients being given the drug just because they asked, if a goddamn doctor wants to do it - they can't now in nevada.
Yeah, that shit is moronic. Patients should be able to take it. Doctors should be able to prescribe it off-label. It's approved for that at the national level... Not saying this shouldn't be used, just saying this site is off its ass about chloroquine on emotion rather than fact.