George Floyd autopsy: 4x's the amount of Fentanyl needed to kill, plus meth and pot.
(www.independentsentinel.com)
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Four times the amount needed to kill someone with no tolerance.....
It's like most people have zero clue how opiate tolerances work.....
A seasoned heroin addict can take 10x+ the "lethal dose" and not even catch a buzz.....
Tolerance to the analgesic and euphoric effects of opioid medications develops much much much more quickly than tolerance to the respiratory depression effects. This is one of the reasons that opioid use is so dangerous and why opioid overdose now kills more people than car crashes. As the user begins to perceive that their usual dosage is no longer effective, they increase the dosage and they stop breathing before they achieve their desired high.
Additionally, the more powerful the opioid, the smaller the margin for error becomes. Fentanyl is in the ball park of 50-100 times more powerful than Morphine, and because it is highly lipid-soluble it has a very easy time getting into the central nervous system. A lot of famous people have died of Fentanyl overdoses including one of my favorite musicians, Tom Petty (though he was taking several other things too).
I've been around the shit my entire life... I know all too well...
None of what you said changes the fact that what science calls a "lethal dose" can be taken 10 times over by seasoned addict and they will barely even feel it. Any of it.
Going off of the lethal dose, which is taken from how much it takes to kill a mouse scaled up to a human's weight, has absolutely nothing to do with a person's "personal lethal dose" when you're talkin about an opiate addict with a very high tolerance.... Their lethal dose will be way the fuck higher than an opiate naive person or mouse, which is exactly what those numbers are derived from.
Only an idiot medical examiner would say something like someone has x number amount of the lethal dose of an opiate, because if they're actual doctors then they fucking know better and they know that statement is completely useless unless you knew the actual tolerance level of the person in question.... that is an utterly useless statement unless you're only talking strictly about opiate naive people, which he clearly wasn't.
This isn't something that can be argued about, it's a fact.
The lethal dose you read about in textbooks doesn't mean a damn thing except for in scientific controls or a person that never takes opiates at all. They don't mean shit on the street where people can bang an entire gram in one shot and not die, even still function like complete normal, but an opiate naive person could take 1/20th of that and kill over in a few minutes....
I do not disagree with you about the statement "4 times the lethal dose" being useless because as you say, the whole concept of LD50 is pretty terrible given that it's extrapolated from creatures that are not humans. That's like saying "I was able to punch a sewing needle through this aluminum foil, so I should easily be able to punch an ice pick through this 1" aluminum plate"