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42
Patriot_Toast 42 points ago +58 / -16

If this shot literally changes your RNA, then it seems to me this could be the long awaited mark of the beast. Particularly if once it's released you have to have documentation just to step foot in any public place. Stay frosty folks, evil is working overtime these days!

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the_hoffman 50 points ago +56 / -6

The shot does not change your RNA. Let me explain why/how.

RNA is just a “photocopy” of DNA that your cells make so they can use them as blueprints to make proteins without having to somehow pull the raw DNA out of the nucleus (library) of the cell.

The RNA is what the cell reads to build proteins, and it is temporary: each photocopy gets degraded after a short while in the cell body. This gives your cells control over what proteins are made, by controlling what DNA is allowed to be photocopied into temporary RNA copies.

When the cell wants to stop making a protein, it stops the DNA sequence that encodes that protein from being photocopied into any more RNA, and so any RNA blueprints still floating around outside the nucleus end up degraded without any more photocopies to replace them, so no more of the protein is made.

The moderna vaccine puts RNA (temporary by definition) into the body of some of your cells, which encodes the spike protein of the coronavirus.

The RNA is used as a blueprint by the cells to make some copies of the spike protein, which the cell presents on its surface and this allows your immune system to recognize the foreign protein and make an immune response against it.

However... because RNA is temporary, it doesn’t last long inside the cells. Just long enough to make some of these proteins, before it gets degraded like all other RNA. (Proteins are also temporary, and they get degraded after some time too, by the way.)

Because this sequence of RNA is simply not part of your genes (meaning, it isn’t in your DNA), there’s no more of it that can be made. So by definition it is temporary.

The concern for safety is not related to whether it will change your genes or do some other weird stuff.

The causes for concern are primarily:

  1. Whether your immune system will “overreact” to the foreign proteins and cause damage through a runaway stress/inflammation response (phase 2 trials have shown this is not the case).

  2. Whether your immune system, having seen these proteins in the vaccine and prepared antibodies & immune cells against them, will mount such an over-the-top response when it sees the actual virus that it will cause more damage than if it hadn’t gotten the vaccine to begin with. This is what current phase 3 trials are seeking to test as we speak.

Keep in mind that this is all just for Moderna’s RNA-based vaccine. Doesn’t apply to vaccines using other approaches.

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FutureMan 5 points ago +9 / -4

So what's the verdict for accepting this vaccine? I was going to stand my ground, but I have a feeling that this will lead to my possible death, as the government might send law enforcement to force me to do it, and that's likely to end up in my death, shot by the cops.

The alternative is accepting the vaccine, and dealing with whatever consequences it brings?

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lalalalal23123 -11 points ago +7 / -18

Please don't be as ignorant as the average /r/politics user. The world isn't creating a vaccine to kill everyone. To even think that is a possibility puts you on the spectrum