The Sandworms and the Spice, the blue of the Spice User's eyes, and the ability of the Navigators to fold time and space, through accelerated evolution, all stem from Frank Herbert's allusion to the Psilocybin Containing Sacred Mushrooms. These secrets exist at the roots of many Religious Traditions Globally, and Herbert conveyed their importance in Spiritual Discovery, as well as his experiential passion for them.

Citation: https://www.dailygrail.com/2014/07/magic-mushrooms-were-the-inspiration-for-frank-herberts-science-fiction-epic-dune/

The new Dune Trailer depicts the worm/ mushroom connection by showing the Worm's "Teeth", as being identical to the gills of the Sacred Mushroom. Director Denis Villeneuve is deeply clued into this historical connection through his art direction throughout the film.

DUNE Trailer 4K (2020) https://www.youtube.com/watch?v=eS0Sdx7AdqI (Worm at the end)

Check out the Top picture on this Pinterest Account for comparison: https://www.pinterest.com/pin/282882420314780988/

Based Hobbit- w/ Special Delivery of Knowledge from The Shire