See my other comment in this thread. You are UNDERcalculating how much fent he had to take to get those blood levels in his body. Fent volume of distribution is about 4L/kg, not just total L of blood.

Also, oral fent bioavailability is only 33%, so what was in his body was only 1/3 of what he took.

Moreover, if those blood levels were free fent (ie not protein bound) then it would be even more, since fent is 80-85% protein bound.

1mg is 1000000ng

Fentanyl volume of distribution is 4L/kg. For a 100kg person it distributes into 400L, or 400000ml. 11ng/ml would mean 4400000ng present in the body or 4.4mg. A 33% oral bioavailability means an oral dose of 13.2mg to achieve those blood levels.

If that’s a free level, it’s even higher of a dose. Since it’s 80-85% protein bound, a free level is only 15-20% of the total drug present in the body. Meaning an oral dose of at least 66mg.

For context, the transdermal patches deliver up to 0.1mg/hr. This dose is usually reserved for cancer patients who have developed resistance to other opioids and lower fent doses. The patch has 92% bioavailability so about 2.8x more drug makes it to the blood, meaning it achieves the same blood level as a 0.28mg oral dose. Since it is PER HOUR, that means the patch delivers the equivalent of 6.72mg orally over 24 hours.

In other words: assuming the PK data are accurate and 11ng/ml was a total fent level, Floyd took about 16hours worth of cancer patient fent all at once.

It’s pretty easy to livestream games for free, without adding to any view numbers. As long as you don’t buy tickets or merch and stream free online you get to enjoy the game without supporting the bolshies.

Yes metro is rough. Potential disulfiram like reactions with alcohol as well. Tough to be on long term.

Thank you for indulging this former pharmacist’s curiosity. Happy for you that you were able to get off that crap.

Narrator: “and bust he did”

Was metro and cipro just for infection prophylaxis with all the immunosuppressive drugs?

Yeah they had started a dumpster fire and he ran over with a fire extinguisher.

Yeah Marin county is not really gonna like that.

Also, poor single mothers won’t be able to afford living in Marin, even with an extra 12k per year. That probably won’t even cover half the rent.

Where did the state get 13%? Taxpayers fund 100% of it.

Morale patches are the patches you see on some people’s plate carriers, helmets, hats, backpacks, or uniform. Sometimes it’s a Bible verse or a slogan. Sometimes it’s a flag or a logo. Sometimes it’s just for a chuckle.

Basically, optional accessory that keeps up your morale.

The lord works in mysterious ways.

And kick it off by a putting out a dumpster fire being rolled towards a gas station, causing a manlet to corner you into grappling over your gun.

What were the pills it replaced? Methotrexate? Xeljanz?

EXACTLY! This is how I knew 100% that the fraud took place. If it hadn’t, they’d have wanted to triple audit every last thing, just so they could turn around and say “See?! We told you he was an evil, lying, divisive fascist!”

In the same vein, if trump knew he lost fair and square then the worst thing to do would be to cry fraud. It would be an easily disprovable lie and he’d be setting himself up to be everything they said he was.

Vaccin macht frei

Traitors are worse than enemies

"If he was black he'd of got the death penalty!"

Nooo you cant just assume just because they were still using hollowed out tree trunks as canoes that they weren't right on the verge of developing blue water vessels!

They were advanced in other ways, they taught the pilgrims corn!

I don't particularly disagree with anything you've said, just specifying the argument made in favor of hate crime legislation.

The juxtaposition between the two crimes is significant in that we live in a racially divided nation and a hate crime puts all folks of one race on notice.

Personally I'm happy with crime being illegal. Motive can come into play when it comes to sentencing, prison housing, or parole. But I don't think hate needs a separate charge.

The same folks that argue for hate crimes under the social fabric argument are the ones who want to do away with gang enhancements because it's racist. They obviously don't care about social fabric, they just want to be woke af.

Easy enough to do. If 10 families pool their tax savings they can hire a dedicated private tutor for their kids.

White people: so racist that when you show up at their door uninvited, they’ll take food out of their kid’s mouth to feed you and their coats to keep you warm.

“DOFO”

He played their game because they told him It’d be his turn.

It was big league, but now it’s never not bigly.

The actual argument is that a hate crime has a worse effect on the community as a whole. The enhancement isn’t for the murdered person, it’s for the social fabric. A robbery gone wrong makes people nervous to go out at night, a proper hate crime makes everyone nervous and distrustful in a multiculti community.

The hitch is that white folks arent exactly running around in the middle of the night pouring bleach on people on their way home from subway and trying to hang them with twine. Almost all hate crimes are done by black people and never get tried as such. Tough to find a group of white people kidnapping a handicapped black person and live-streaming the torture, or chanting kill blackie, or saying on Twatter how black people should all be killed for the alleged crimes of long dead people who share a hue.