To enter the healthy adult brain, molecules must either cross the micro vessel endothelial cells by transcytosis, or similarly be secreted into the CSF by the choroid plexus.
It is noteworthy that the inflammation and immune reaction causes large numbers of microphages to migrate from the blood between the micro vessel endothelial cells and into the brain. This disrupts the tight junction boundaries and inevitably causes the BBB to become more leaky. The spike proteins caused this, but only indirectly.
Yep, endothelial cells. These are the cells that physically manifest the BBB, by virtue of tight junctions between these cells that line the microvasculature. If any given molecule binds to or even enters the brain endothelial cells, it still hasn’t passed the BBB and entered the brain parenchyma.
Trust me, I love this shit. Studied it for years.
https://www.mdpi.com/2076-393X/10/10/1651
This case study observes spike staining “in the brain” but not technically inside the BBB - it’s all in the endothelial blood vessel cells. This was all easily predicted based on the ACE2 receptor binding domain in the spike protein and the prevalence of ACE2 receptor expression in vascular endothelial cells. Not much evidence that spike itself moves past the barrier, just that it disrupts the barrier and normal blood flow, causing neuropathology.
Spike proteins don’t need to cross the BBB to damage it thru inflammation and immune response. Neurotoxic chemicals leak in while blood flow is interrupted, multi focal (global) necrosis ensues, the subject reverts to primitive behaviors.
What mods are you interested in?